Rho GTPases orient directional sensing in chemotaxis
نویسندگان
چکیده
منابع مشابه
Rho GTPases orient directional sensing in chemotaxis.
During chemotaxis, cells sense extracellular chemical gradients and position Ras GTPase activation and phosphatidylinositol (3,4,5)-triphosphate (PIP3) production toward chemoattractants. These two major signaling events are visualized by biosensors in a crescent-like zone at the plasma membrane. Here, we show that a Dictyostelium Rho GTPase, RacE, and a guanine nucleotide exchange factor, GxcT...
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Cell migration is a complex, dynamic process that involves continuous remodeling of the cellular architecture, which is needed in order for the cell to move and adapt to changes in the surrounding environment. It requires rapidly activated and spatiotemporally regulated signaling networks that enable cellular responses to external cues. Rho-family GTPases are key components of these signaling n...
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The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti, 1999). ECM components can signal directly to cells through transmembrane receptors such as inte-grins, and can also present soluble cytokines and growth factors to cells. The morphology of cells varies great...
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In his review of the Ras family in 1988, Pierre Chardin speculated that an obscure subfamily of the Ras superfamily, which at that time was only known in yeast, would be conserved in mammals. He was of course right, and today the number of labs and the amount of effort being expended to understand the vast network of Rho-family signaling is enormous. Given their fundamental role in normal and d...
متن کاملReceptor noise and directional sensing in eukaryotic chemotaxis.
Chemotacting eukaryotic cells are able to detect very small chemical gradients (approximately 1%) for a large range of background concentrations. For these chemical environments, fluctuations in the number of bound ligands will become important. Here, we investigate the effect of receptor noise in a simplified one-dimensional geometry. The auto- and cross-correlations of the noise sources at th...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1312540110